Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Identifieur interne : 000A47 ( Main/Exploration ); précédent : 000A46; suivant : 000A48Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Auteurs : Stephen Salloway [Royaume-Uni] ; Reisa Sperling ; Nick C. Fox ; Kaj Blennow ; William Klunk ; Murray Raskind ; Marwan Sabbagh ; Lawrence S. Honig ; Anton P. Porsteinsson ; Steven Ferris ; Marcel Reichert ; Nzeera Ketter ; Bijan Nejadnik ; Volkmar Guenzler ; Maja Miloslavsky ; Daniel Wang ; Yuan Lu ; Julia Lull ; Iulia Cristina Tudor ; Enchi Liu ; Michael Grundman ; Eric Yuen ; Ronald Black ; H Robert BrashearSource :
- The New England journal of medicine [ 1533-4406 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Analyse de l'intention de traiter, Anticorps monoclonaux humanisés (effets indésirables), Anticorps monoclonaux humanisés (usage thérapeutique), Apolipoprotéines E (génétique), Cognition (), Encéphale (anatomopathologie), Femelle, Humains, Indice de gravité médicale, Maladie d'Alzheimer (), Maladie d'Alzheimer (génétique), Maladie d'Alzheimer (traitement médicamenteux), Marqueurs biologiques (), Marqueurs biologiques (analyse), Mâle, Méthode en double aveugle, Oedème (), Peptides bêta-amyloïdes (), Peptides bêta-amyloïdes (analyse), Peptides bêta-amyloïdes (antagonistes et inhibiteurs), Phosphorylation, Protéines tau (), Sujet âgé, Sujet âgé de 80 ans ou plus, Tests neuropsychologiques, Tomographie par émission de positons, Échec thérapeutique.
- MESH :
- analyse : Marqueurs biologiques, Peptides bêta-amyloïdes.
- anatomopathologie : Encéphale.
- antagonistes et inhibiteurs : Peptides bêta-amyloïdes.
- effets indésirables : Anticorps monoclonaux humanisés.
- génétique : Apolipoprotéines E, Maladie d'Alzheimer.
- traitement médicamenteux : Maladie d'Alzheimer.
- usage thérapeutique : Anticorps monoclonaux humanisés.
- Adulte d'âge moyen, Analyse de l'intention de traiter, Cognition, Femelle, Humains, Indice de gravité médicale, Maladie d'Alzheimer, Marqueurs biologiques, Mâle, Méthode en double aveugle, Oedème, Peptides bêta-amyloïdes, Phosphorylation, Protéines tau, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests neuropsychologiques, Tomographie par émission de positons, Échec thérapeutique.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Alzheimer Disease (cerebrospinal fluid), Alzheimer Disease (drug therapy), Alzheimer Disease (genetics), Amyloid beta-Peptides (analysis), Amyloid beta-Peptides (antagonists & inhibitors), Amyloid beta-Peptides (cerebrospinal fluid), Antibodies, Monoclonal, Humanized (adverse effects), Antibodies, Monoclonal, Humanized (therapeutic use), Apolipoproteins E (genetics), Biomarkers (analysis), Biomarkers (cerebrospinal fluid), Brain (pathology), Cognition (drug effects), Double-Blind Method, Edema (chemically induced), Female, Humans, Intention to Treat Analysis, Male, Middle Aged, Neuropsychological Tests, Phosphorylation, Positron-Emission Tomography, Severity of Illness Index, Treatment Failure, tau Proteins (cerebrospinal fluid).
- MESH :
- chemical , adverse effects : Antibodies, Monoclonal, Humanized.
- chemical , analysis : Amyloid beta-Peptides, Biomarkers.
- chemical , antagonists & inhibitors : Amyloid beta-Peptides.
- cerebrospinal fluid : Alzheimer Disease, Amyloid beta-Peptides, Biomarkers, tau Proteins.
- chemically induced : Edema.
- drug effects : Cognition.
- drug therapy : Alzheimer Disease.
- genetics : Alzheimer Disease, Apolipoproteins E.
- pathology : Brain.
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized.
- Aged, Aged, 80 and over, Double-Blind Method, Female, Humans, Intention to Treat Analysis, Male, Middle Aged, Neuropsychological Tests, Phosphorylation, Positron-Emission Tomography, Severity of Illness Index, Treatment Failure.
Abstract
Bapineuzumab, a humanized anti-amyloid-beta monoclonal antibody, is in clinical development for the treatment of Alzheimer's disease.
DOI: 10.1056/NEJMoa1304839
PubMed: 24450891
Affiliations:
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Le document en format XML
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Fox</name></author><author><name sortKey="Blennow, Kaj" sort="Blennow, Kaj" uniqKey="Blennow K" first="Kaj" last="Blennow">Kaj Blennow</name></author><author><name sortKey="Klunk, William" sort="Klunk, William" uniqKey="Klunk W" first="William" last="Klunk">William Klunk</name></author><author><name sortKey="Raskind, Murray" sort="Raskind, Murray" uniqKey="Raskind M" first="Murray" last="Raskind">Murray Raskind</name></author><author><name sortKey="Sabbagh, Marwan" sort="Sabbagh, Marwan" uniqKey="Sabbagh M" first="Marwan" last="Sabbagh">Marwan Sabbagh</name></author><author><name sortKey="Honig, Lawrence S" sort="Honig, Lawrence S" uniqKey="Honig L" first="Lawrence S" last="Honig">Lawrence S. Honig</name></author><author><name sortKey="Porsteinsson, Anton P" sort="Porsteinsson, Anton P" uniqKey="Porsteinsson A" first="Anton P" last="Porsteinsson">Anton P. Porsteinsson</name></author><author><name sortKey="Ferris, Steven" sort="Ferris, Steven" uniqKey="Ferris S" first="Steven" last="Ferris">Steven Ferris</name></author><author><name sortKey="Reichert, Marcel" sort="Reichert, Marcel" uniqKey="Reichert M" first="Marcel" last="Reichert">Marcel Reichert</name></author><author><name sortKey="Ketter, Nzeera" sort="Ketter, Nzeera" uniqKey="Ketter N" first="Nzeera" last="Ketter">Nzeera Ketter</name></author><author><name sortKey="Nejadnik, Bijan" sort="Nejadnik, Bijan" uniqKey="Nejadnik B" first="Bijan" last="Nejadnik">Bijan Nejadnik</name></author><author><name sortKey="Guenzler, Volkmar" sort="Guenzler, Volkmar" uniqKey="Guenzler V" first="Volkmar" last="Guenzler">Volkmar Guenzler</name></author><author><name sortKey="Miloslavsky, Maja" sort="Miloslavsky, Maja" uniqKey="Miloslavsky M" first="Maja" last="Miloslavsky">Maja Miloslavsky</name></author><author><name sortKey="Wang, Daniel" sort="Wang, Daniel" uniqKey="Wang D" first="Daniel" last="Wang">Daniel Wang</name></author><author><name sortKey="Lu, Yuan" sort="Lu, Yuan" uniqKey="Lu Y" first="Yuan" last="Lu">Yuan Lu</name></author><author><name sortKey="Lull, Julia" sort="Lull, Julia" uniqKey="Lull J" first="Julia" last="Lull">Julia Lull</name></author><author><name sortKey="Tudor, Iulia Cristina" sort="Tudor, Iulia Cristina" uniqKey="Tudor I" first="Iulia Cristina" last="Tudor">Iulia Cristina Tudor</name></author><author><name sortKey="Liu, Enchi" sort="Liu, Enchi" uniqKey="Liu E" first="Enchi" last="Liu">Enchi Liu</name></author><author><name sortKey="Grundman, Michael" sort="Grundman, Michael" uniqKey="Grundman M" first="Michael" last="Grundman">Michael Grundman</name></author><author><name sortKey="Yuen, Eric" sort="Yuen, Eric" uniqKey="Yuen E" first="Eric" last="Yuen">Eric Yuen</name></author><author><name sortKey="Black, Ronald" sort="Black, Ronald" uniqKey="Black R" first="Ronald" last="Black">Ronald Black</name></author><author><name sortKey="Brashear, H Robert" sort="Brashear, H Robert" uniqKey="Brashear H" first="H Robert" last="Brashear">H Robert Brashear</name></author></analytic><series><title level="j">The New England journal of medicine</title><idno type="eISSN">1533-4406</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alzheimer Disease (cerebrospinal fluid)</term><term>Alzheimer Disease (drug therapy)</term><term>Alzheimer Disease (genetics)</term><term>Amyloid beta-Peptides (analysis)</term><term>Amyloid beta-Peptides (antagonists & inhibitors)</term><term>Amyloid beta-Peptides (cerebrospinal fluid)</term><term>Antibodies, Monoclonal, Humanized (adverse effects)</term><term>Antibodies, Monoclonal, Humanized (therapeutic use)</term><term>Apolipoproteins E (genetics)</term><term>Biomarkers (analysis)</term><term>Biomarkers (cerebrospinal fluid)</term><term>Brain (pathology)</term><term>Cognition (drug effects)</term><term>Double-Blind Method</term><term>Edema (chemically induced)</term><term>Female</term><term>Humans</term><term>Intention to Treat Analysis</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Phosphorylation</term><term>Positron-Emission Tomography</term><term>Severity of Illness Index</term><term>Treatment Failure</term><term>tau Proteins (cerebrospinal fluid)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de l'intention de traiter</term><term>Anticorps monoclonaux humanisés (effets indésirables)</term><term>Anticorps monoclonaux humanisés (usage thérapeutique)</term><term>Apolipoprotéines E (génétique)</term><term>Cognition ()</term><term>Encéphale (anatomopathologie)</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Maladie d'Alzheimer ()</term><term>Maladie d'Alzheimer (génétique)</term><term>Maladie d'Alzheimer (traitement médicamenteux)</term><term>Marqueurs biologiques ()</term><term>Marqueurs biologiques (analyse)</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Oedème ()</term><term>Peptides bêta-amyloïdes ()</term><term>Peptides bêta-amyloïdes (analyse)</term><term>Peptides bêta-amyloïdes (antagonistes et inhibiteurs)</term><term>Phosphorylation</term><term>Protéines tau ()</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests neuropsychologiques</term><term>Tomographie par émission de positons</term><term>Échec thérapeutique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Amyloid beta-Peptides</term><term>Biomarkers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Amyloid beta-Peptides</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Marqueurs biologiques</term><term>Peptides bêta-amyloïdes</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphale</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Peptides bêta-amyloïdes</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Alzheimer Disease</term><term>Amyloid beta-Peptides</term><term>Biomarkers</term><term>tau Proteins</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Edema</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cognition</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alzheimer Disease</term><term>Apolipoproteins E</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Apolipoprotéines E</term><term>Maladie d'Alzheimer</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladie d'Alzheimer</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Intention to Treat Analysis</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Phosphorylation</term><term>Positron-Emission Tomography</term><term>Severity of Illness Index</term><term>Treatment Failure</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de l'intention de traiter</term><term>Cognition</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Maladie d'Alzheimer</term><term>Marqueurs biologiques</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Oedème</term><term>Peptides bêta-amyloïdes</term><term>Phosphorylation</term><term>Protéines tau</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests neuropsychologiques</term><term>Tomographie par émission de positons</term><term>Échec thérapeutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bapineuzumab, a humanized anti-amyloid-beta monoclonal antibody, is in clinical development for the treatment of Alzheimer's disease.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><noCountry><name sortKey="Black, Ronald" sort="Black, Ronald" uniqKey="Black R" first="Ronald" last="Black">Ronald Black</name><name sortKey="Blennow, Kaj" sort="Blennow, Kaj" uniqKey="Blennow K" first="Kaj" last="Blennow">Kaj Blennow</name><name sortKey="Brashear, H Robert" sort="Brashear, H Robert" uniqKey="Brashear H" first="H Robert" last="Brashear">H Robert Brashear</name><name sortKey="Ferris, Steven" sort="Ferris, Steven" uniqKey="Ferris S" first="Steven" last="Ferris">Steven Ferris</name><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C" last="Fox">Nick C. Fox</name><name sortKey="Grundman, Michael" sort="Grundman, Michael" uniqKey="Grundman M" first="Michael" last="Grundman">Michael Grundman</name><name sortKey="Guenzler, Volkmar" sort="Guenzler, Volkmar" uniqKey="Guenzler V" first="Volkmar" last="Guenzler">Volkmar Guenzler</name><name sortKey="Honig, Lawrence S" sort="Honig, Lawrence S" uniqKey="Honig L" first="Lawrence S" last="Honig">Lawrence S. Honig</name><name sortKey="Ketter, Nzeera" sort="Ketter, Nzeera" uniqKey="Ketter N" first="Nzeera" last="Ketter">Nzeera Ketter</name><name sortKey="Klunk, William" sort="Klunk, William" uniqKey="Klunk W" first="William" last="Klunk">William Klunk</name><name sortKey="Liu, Enchi" sort="Liu, Enchi" uniqKey="Liu E" first="Enchi" last="Liu">Enchi Liu</name><name sortKey="Lu, Yuan" sort="Lu, Yuan" uniqKey="Lu Y" first="Yuan" last="Lu">Yuan Lu</name><name sortKey="Lull, Julia" sort="Lull, Julia" uniqKey="Lull J" first="Julia" last="Lull">Julia Lull</name><name sortKey="Miloslavsky, Maja" sort="Miloslavsky, Maja" uniqKey="Miloslavsky M" first="Maja" last="Miloslavsky">Maja Miloslavsky</name><name sortKey="Nejadnik, Bijan" sort="Nejadnik, Bijan" uniqKey="Nejadnik B" first="Bijan" last="Nejadnik">Bijan Nejadnik</name><name sortKey="Porsteinsson, Anton P" sort="Porsteinsson, Anton P" uniqKey="Porsteinsson A" first="Anton P" last="Porsteinsson">Anton P. Porsteinsson</name><name sortKey="Raskind, Murray" sort="Raskind, Murray" uniqKey="Raskind M" first="Murray" last="Raskind">Murray Raskind</name><name sortKey="Reichert, Marcel" sort="Reichert, Marcel" uniqKey="Reichert M" first="Marcel" last="Reichert">Marcel Reichert</name><name sortKey="Sabbagh, Marwan" sort="Sabbagh, Marwan" uniqKey="Sabbagh M" first="Marwan" last="Sabbagh">Marwan Sabbagh</name><name sortKey="Sperling, Reisa" sort="Sperling, Reisa" uniqKey="Sperling R" first="Reisa" last="Sperling">Reisa Sperling</name><name sortKey="Tudor, Iulia Cristina" sort="Tudor, Iulia Cristina" uniqKey="Tudor I" first="Iulia Cristina" last="Tudor">Iulia Cristina Tudor</name><name sortKey="Wang, Daniel" sort="Wang, Daniel" uniqKey="Wang D" first="Daniel" last="Wang">Daniel Wang</name><name sortKey="Yuen, Eric" sort="Yuen, Eric" uniqKey="Yuen E" first="Eric" last="Yuen">Eric Yuen</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Salloway, Stephen" sort="Salloway, Stephen" uniqKey="Salloway S" first="Stephen" last="Salloway">Stephen Salloway</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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